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Structure Based Design of Covalent Siah Inhibitors
The E3 ubiquitin ligase Siah regulates key cellular events that are central to cancer development and progression. A promising route to Siah inhibition is disrupting its interactions with adaptor proteins. However, typical of protein-protein interactions, traditional unbiased approaches to ligand di...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763817/ https://ncbi.nlm.nih.gov/pubmed/23891150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.06.008 |
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