Structure Based Design of Covalent Siah Inhibitors

The E3 ubiquitin ligase Siah regulates key cellular events that are central to cancer development and progression. A promising route to Siah inhibition is disrupting its interactions with adaptor proteins. However, typical of protein-protein interactions, traditional unbiased approaches to ligand di...

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Detalhes bibliográficos
Main Authors: Stebbins, John L., Santelli, Eugenio, Feng, Yongmei, De, Surya K., Purves, Angela, Motamedchaboki, Khatereh, Wu, Bainan, Ronai, Ze’ev A., Liddington, Robert C., Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763817/
https://ncbi.nlm.nih.gov/pubmed/23891150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.06.008
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