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The Ubiquitin Ligase Siah2 and the Hypoxia Response

Growing evidence indicates that ubiquitin ligases play a critical role in the hypoxia response. Among them, Siah2, a RING finger ligase, is an important regulator of pathways activated under hypoxia. Siah2 regulates prolyl hydroxylases PHD3 and 1 under oxygen concentration of 2% to 5%, thereby allow...

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Autors principals: Nakayama, Koh, Qi, Jianfei, Ronai, Ze’ev
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860273/
https://ncbi.nlm.nih.gov/pubmed/19372575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0458
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