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Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2
PHD1–3 (prolyl hydroxylases 1–3) catalyse the hydroxylation of HIF (hypoxia-inducible factor)-α subunit that triggers the substrate ubiquitination and subsequent degradation. The RING (really interesting new gene) finger E3 ligase Siah2 preferentially targets PHD3 for degradation. Here, we identify...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698661/ https://ncbi.nlm.nih.gov/pubmed/16958618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061135 |
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