Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

PHD1–3 (prolyl hydroxylases 1–3) catalyse the hydroxylation of HIF (hypoxia-inducible factor)-α subunit that triggers the substrate ubiquitination and subsequent degradation. The RING (really interesting new gene) finger E3 ligase Siah2 preferentially targets PHD3 for degradation. Here, we identify...

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Bibliographische Detailangaben
Hauptverfasser: Nakayama, Koh, Gazdoiu, Stefan, Abraham, Robert, Pan, Zhen-Qiang, Ronai, Ze'ev
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698661/
https://ncbi.nlm.nih.gov/pubmed/16958618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061135
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