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Regulation of the Ring Finger E3 Ligase Siah2 by p38 MAPK
The RING finger ubiquitin ligase Siah2 controls the stability of various substrates involved in stress and hypoxia responses, including the PHD3, which controls the stability of HIF-1α. In the present study we determined the role of Siah2 phosphorylation in the regulation of its activity toward PHD3...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954258/ https://ncbi.nlm.nih.gov/pubmed/17003045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M606568200 |
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