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STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF Bcl-x(L) ANTAGONISTS

Apoptosis, or programmed cell death, plays a key role in normal tissue homeostasis ensuring a proper balance between cell production and cell loss. Anti-apoptotic Bcl-2-family proteins are central regulators of the apoptotic pathway and due to their ability to confer tumor resistance to chemotherapy...

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Detalhes bibliográficos
Main Authors: Rega, Michele F., Leone, Marilisa, Jung, Dawoon, Cotton, Naomi J.H., Stebbins, John L., Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2023964/
https://ncbi.nlm.nih.gov/pubmed/17512966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2007.03.001
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