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STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF Bcl-x(L) ANTAGONISTS
Apoptosis, or programmed cell death, plays a key role in normal tissue homeostasis ensuring a proper balance between cell production and cell loss. Anti-apoptotic Bcl-2-family proteins are central regulators of the apoptotic pathway and due to their ability to confer tumor resistance to chemotherapy...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2023964/ https://ncbi.nlm.nih.gov/pubmed/17512966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2007.03.001 |
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