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SAR by Inter-Ligand nuclear Overhauser Effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1
Over expression of anti-apoptotic members of the Bcl-2 family proteins, such as Bcl-x(L) and Mfl-1 has been shown to be involved in resistance to chemotherapeutic drugs in many forms of cancers. Recent efforts from the Abbott Laboratories resulted in the development of the acylsulfonamide compound a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165075/ https://ncbi.nlm.nih.gov/pubmed/21797225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200826s |
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