HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

Fragment-based ligand design (FBLD) approaches have become more widely used in drug discovery projects from both academia and industry, and are even often preferred to traditional high-throughput screening (HTS) of large collection of compounds (>10(5)). A key advantage of FBLD approaches is that...

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Main Authors: Wu, Bainan, Zhang, Ziming, Noberini, Roberta, Barile, Elisa, Giulianotti, Marc, Pinilla, Clemencia, Houghten, Richard A., Pasquale, Elena B., Pellecchia, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966493/
https://ncbi.nlm.nih.gov/pubmed/23352136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.10.015
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