Sabutoclax, a Mcl-1 Antagonist, Inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer

Resistance to available therapeutic agents has been a common problem thwarting progress in treatment of castrate-resistant and metastatic prostate cancer (PCa). Overexpression of the Bcl-2 family members, including Mcl-1, in PCa cells is known to inhibit intracellular mitochondrial-dependent apoptos...

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Autori principali: Jackson, Roger S, Placzek, William, Fernandez, Ana, Ziaee, Shabnam, Chu, Chia-Yi, Wei, Jun, Stebbins, John, Kitada, Shinichi, Fritz, Gloria, Reed, John C, Chung, Leland W, Pellecchia, Maurizio, Bhowmick, Neil A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421961/
https://ncbi.nlm.nih.gov/pubmed/22904682
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