Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), an IL-10 family cytokine, exhibits pleiotropic anticancer activities without adversely affecting normal cells. We previously demonstrated t...

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Bibliografische gegevens
Hoofdauteurs: Dash, Rupesh, Azab, Belal, Quinn, Bridget A., Shen, Xuening, Wang, Xiang-Yang, Das, Swadesh K., Rahmani, Mohamed, Wei, Jun, Hedvat, Michael, Dent, Paul, Dmitriev, Igor P., Curiel, David T., Grant, Steven, Wu, Bainan, Stebbins, John L., Pellecchia, Maurizio, Reed, John C., Sarkar, Devanand, Fisher, Paul B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102401/
https://ncbi.nlm.nih.gov/pubmed/21555592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100769108
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