Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity

Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), an IL-10 family cytokine, exhibits pleiotropic anticancer activities without adversely affecting normal cells. We previously demonstrated t...

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Detalhes bibliográficos
Main Authors: Dash, Rupesh, Azab, Belal, Quinn, Bridget A., Shen, Xuening, Wang, Xiang-Yang, Das, Swadesh K., Rahmani, Mohamed, Wei, Jun, Hedvat, Michael, Dent, Paul, Dmitriev, Igor P., Curiel, David T., Grant, Steven, Wu, Bainan, Stebbins, John L., Pellecchia, Maurizio, Reed, John C., Sarkar, Devanand, Fisher, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102401/
https://ncbi.nlm.nih.gov/pubmed/21555592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100769108
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