A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

We investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily members in 68 human cancer cell lines using qPCR techniques and measured the ability of known Bcl-2 inhibitors to induce cell death in 36 of the studied tumor cell lines. Our study reveals that Mcl-1 represents the a...

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Detalhes bibliográficos
Main Authors: Placzek, W J, Wei, J, Kitada, S, Zhai, D, Reed, J C, Pellecchia, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032312/
https://ncbi.nlm.nih.gov/pubmed/21364647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.18
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