Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Altered expression of Bcl-2 family proteins plays central roles in apoptosis dysregulation in cancer and leukemia, promoting malignant cell expansion and contributing to chemoresistance. In this study, we compared the toxicity and efficacy in mice of natural product gossypol and its semisynthetic de...

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Bibliographic Details
Main Authors: Kitada, Shinichi, Kress, Christina L., Krajewska, Maryla, Jia, Lee, Pellecchia, Maurizio, Reed, John C.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265458/
https://ncbi.nlm.nih.gov/pubmed/18202226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113647
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