Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth()

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Remacle, Albert G., Golubkov, Vladislav S., Shiryaev, Sergey A., Dahl, Russell, Stebbins, John L., Chernov, Andrei V., Cheltsov, Anton V., Pellecchia, Maurizio, Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342448/
https://ncbi.nlm.nih.gov/pubmed/22406620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4149
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados