Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth()

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and,...

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Detaylı Bibliyografya
Asıl Yazarlar: Remacle, Albert G., Golubkov, Vladislav S., Shiryaev, Sergey A., Dahl, Russell, Stebbins, John L., Chernov, Andrei V., Cheltsov, Anton V., Pellecchia, Maurizio, Strongin, Alex Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342448/
https://ncbi.nlm.nih.gov/pubmed/22406620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4149
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