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Design and characterization of a potent and selective dual ATP- and substrate-competitive sub-nanomolar bi-dentate c-Jun N-terminal Kinase (JNK) inhibitor

c-Jun N-terminal Kinases (JNKs) represent valuable targets in the development of new therapies. Present on the surface of JNK is a binding pocket for substrates and the scaffolding protein JIP1 in close proximity to the ATP binding pocket. We propose that bi-dentate compounds linking the binding ene...

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Detalles Bibliográficos
Main Authors: Stebbins, John L., De, Surya K., Pavlickova, Petra, Chen, Vida, Machleidt, Thomas, Chen, Li-Hsing, Kuntzen, Christian, Kitada, Shinichi, Karin, Michael, Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174326/
https://ncbi.nlm.nih.gov/pubmed/21815634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200479c
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