Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identification of potent and selective JNK inhibitors t...

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Detalhes bibliográficos
Main Authors: De, Surya K., Chen, Vida, Stebbins, John L., Chen, Li-Hsing, Cellitti, Jason F., Machleidt, Thomas, Barile, Elisa, Riel-Mehan, Megan, Dahl, Russell, Yang, Li, Emdadi, Aras, Murphy, Ria, Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818674/
https://ncbi.nlm.nih.gov/pubmed/20045647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.013
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