Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse

Por Tidball, James G, Spencer, Melissa J
Publicado em 2002

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

Por Kudryashova, Elena, Kramerova, Irina, Spencer, Melissa J.
Publicado em 2012

Autolytic Activation of Calpain 3 Proteinase Is Facilitated by Calmodulin Protein

Por Ermolova, Natalia, Kramerova, Irina, Spencer, Melissa J.
Publicado no J Biol Chem (2015)

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

Por Wehling, Michelle, Spencer, Melissa J., Tidball, James G.
Publicado em 2001

Regulation of the M-Cadherin-β-Catenin Complex by Calpain 3 during Terminal Stages of Myogenic Differentiation

Por Kramerova, Irina, Kudryashova, Elena, Wu, Benjamin, Spencer, Melissa J.
Publicado em 2006

Outside in: the matrix as a modifier of muscular dystrophy

Por Quattrocelli, Mattia, Spencer, Melissa J., McNally, Elizabeth M.
Publicado no Biochim Biophys Acta (2016)

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

Por Kudryashova, Elena, Wu, Jun, Havton, Leif A., Spencer, Melissa J.
Publicado em 2009

Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein

Por Nazarian, Ramin, Starcevic, Marta, Spencer, Melissa J., Dell'Angelica, Esteban C.
Publicado em 2006

Emerging genetic therapies to treat Duchenne muscular dystrophy

Por Nelson, Stanley F., Crosbie, Rachelle H., Miceli, M. Carrie, Spencer, Melissa J.
Publicado em 2009

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype

Por Kudryashova, Elena, Struyk, Arie, Mokhonova, Ekaterina, Cannon, Stephen C., Spencer, Melissa J.
Publicado em 2011

Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy

Por Young, Courtney S., Mokhonova, Ekaterina, Quinonez, Marbella, Pyle, April D., Spencer, Melissa J.
Publicado no J Neuromuscul Dis (2017)

Eosinophilia of Dystrophin-Deficient Muscle Is Promoted by Perforin-Mediated Cytotoxicity by T Cell Effectors

Por Cai, Baiyuan, Spencer, Melissa J., Nakamura, Gerald, Tseng-Ong, Linda, Tidball, James G.
Publicado em 2000

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

Por Kramerova, Irina, Kudryashova, Elena, Wu, Benjamin, Ottenheijm, Coen, Granzier, Henk, Spencer, Melissa J.
Publicado em 2008

Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3

Por Ermolova, Natalia, Kudryashova, Elena, DiFranco, Marino, Vergara, Julio, Kramerova, Irina, Spencer, Melissa J.
Publicado em 2011

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2

Por Mokhonova, Ekaterina I., Avliyakulov, Nuraly K., Kramerova, Irina, Kudryashova, Elena, Haykinson, Michael J., Spencer, Melissa J.
Publicado no Hum Mol Genet (2015)

A reporter mouse for optical imaging of inflammation in mdx muscles

Por Martinez, Leonel, Ermolova, Natalia V, Ishikawa, Tomo-O, Stout, David B, Herschman, Harvey R, Spencer, Melissa J
Publicado no Skelet Muscle (2015)

mdm Muscular Dystrophy: Interactions with Calpain 3 and a Novel Functional Role for Titin’s N2A Domain

Por Huebsch, Kimberly A., Kudryashova, Elena, Wooley, Christine M., Sher, Roger B., Seburn, Kevin L., Spencer, Melissa J., Cox, Gregory A.
Publicado em 2005

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype

Por Capote, Joana, Kramerova, Irina, Martinez, Leonel, Vetrone, Sylvia, Barton, Elisabeth R., Sweeney, H. Lee, Miceli, M. Carrie, Spencer, Melissa J.
Publicado no J Cell Biol (2016)

Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle

Por Kramerova, Irina, Kudryashova, Elena, Wu, Benjamin, Germain, Sean, Vandenborne, Krista, Romain, Nadine, Haller, Ronald G., Verity, M. Anthony, Spencer, Melissa J.
Publicado em 2009

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

Por Villalta, S. Armando, Rosenthal, Wendy, Martinez, Leonel, Kaur, Amanjot, Sparwasser, Tim, Tidball, James G., Margeta, Marta, Spencer, Melissa J., Bluestone, Jeffrey A.
Publicado no Sci Transl Med (2014)