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Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

Mutations in the E3 ubiquitin ligase tripartite motif-containing 32 (TRIM32) are responsible for the disease limb-girdle muscular dystrophy 2H (LGMD2H). Previously, we generated Trim32 knockout mice (Trim32(–/–) mice) and showed that they display a myopathic phenotype accompanied by neurogenic featu...

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Detalhes bibliográficos
Main Authors: Kudryashova, Elena, Kramerova, Irina, Spencer, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336976/
https://ncbi.nlm.nih.gov/pubmed/22505452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59581
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