Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients

Por Negishi, Mayumi, Shimomura, Kenju, Proks, Peter, Shimomura, Yohnosuke, Mori, Masatomo
Publicado em 2008

Development of postpartum Graves’ disease and type 1 diabetes after delivery in a patient with gestational diabetes

Por Negishi, Mayumi, Shimomura, Kenju, Proks, Peter, Nakahara, Rieko, Murakami, Masami, Shimomura, Yohnosuke, Kobayashi, Isao
Publicado em 2011

A universally conserved residue in the SUR1 subunit of the K(ATP) channel is essential for translating nucleotide binding at SUR1 into channel opening

Por de Wet, Heidi, Shimomura, Kenju, Aittoniemi, Jussi, Ahmad, Nawaz, Lafond, Mathilde, Sansom, Mark SP, Ashcroft, Frances M
Publicado em 2012

Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca(2+) response to glucose

Por Yanagida, Kazuhiro, Maejima, Yuko, Santoso, Putra, Otgon-Uul, Zesemdorj, Yang, Yifei, Sakuma, Kazuya, Shimomura, Kenju, Yada, Toshihiko
Publicado em 2014

Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

Por Iwasaki, Yusaku, Shimomura, Kenju, Kohno, Daisuke, Dezaki, Katsuya, Ayush, Enkh-Amar, Nakabayashi, Hajime, Kubota, Naoto, Kadowaki, Takashi, Kakei, Masafumi, Nakata, Masanori, Yada, Toshihiko
Publicado em 2013

3-D structural and functional characterization of the purified K(ATP) channel complex Kir6.2–SUR1

Por Mikhailov, Michael V, Campbell, Jeff D, de Wet, Heidi, Shimomura, Kenju, Zadek, Brittany, Collins, Richard F, Sansom, Mark S P, Ford, Robert C, Ashcroft, Frances M
Publicado em 2005

Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes

Por de Wet, Heidi, Rees, Mathew G., Shimomura, Kenju, Aittoniemi, Jussi, Patch, Ann-Marie, Flanagan, Sarah E., Ellard, Sian, Hattersley, Andrew T., Sansom, Mark S. P., Ashcroft, Frances M.
Publicado em 2007

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

Por Goldsworthy, Michelle, Hugill, Alison, Freeman, Helen, Horner, Emma, Shimomura, Kenju, Bogani, Debora, Pieles, Guido, Mijat, Vesna, Arkell, Ruth, Bhattacharya, Shoumo, Ashcroft, Frances M., Cox, Roger D.
Publicado em 2008

pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β cells

Por Zehetner, Jens, Danzer, Carsten, Collins, Stephan, Eckhardt, Katrin, Gerber, Philipp A., Ballschmieter, Pia, Galvanovskis, Juris, Shimomura, Kenju, Ashcroft, Frances M., Thorens, Bernard, Rorsman, Patrik, Krek, Wilhelm
Publicado em 2008

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Por Shimomura, Kenju, Tusa, Maija, Iberl, Michaela, Brereton, Melissa F., Kaizik, Stephan, Proks, Peter, Lahmann, Carolina, Yaluri, Nagendra, Modi, Shalem, Huopio, Hanna, Ustinov, Jarkko, Otonkoski, Timo, Laakso, Markku, Ashcroft, Frances M.
Publicado em 2013

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Por Brereton, Melissa F., Rohm, Maria, Shimomura, Kenju, Holland, Christian, Tornovsky-Babeay, Sharona, Dadon, Daniela, Iberl, Michaela, Chibalina, Margarita V., Lee, Sheena, Glaser, Benjamin, Dor, Yuval, Rorsman, Patrik, Clark, Anne, Ashcroft, Frances M.
Publicado no Nat Commun (2016)

Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism

Por Shimomura, Kenju, Flanagan, Sarah E, Zadek, Brittany, Lethby, Mark, Zubcevic, Lejla, Girard, Christophe A J, Petz, Oliver, Mannikko, Roope, Kapoor, Ritika R, Hussain, Khalid, Skae, Mars, Clayton, Peter, Hattersley, Andrew, Ellard, Sian, Ashcroft, Frances M
Publicado em 2009

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Por Brereton, Melissa F., Iberl, Michaela, Shimomura, Kenju, Zhang, Quan, Adriaenssens, Alice E., Proks, Peter, Spiliotis, Ioannis I., Dace, William, Mattis, Katia K., Ramracheya, Reshma, Gribble, Fiona M., Reimann, Frank, Clark, Anne, Rorsman, Patrik, Ashcroft, Frances M.
Publicado em 2014

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

Por Medina-Gomez, Gema, Gray, Sarah L, Yetukuri, Laxman, Shimomura, Kenju, Virtue, Sam, Campbell, Mark, Curtis, R. Keira, Jimenez-Linan, Mercedes, Blount, Margaret, Yeo, Giles S. H, Lopez, Miguel, Seppänen-Laakso, Tuulikki, Ashcroft, Frances M, Orešič, Matej, Vidal-Puig, Antonio
Publicado em 2007

Permanent Neonatal Diabetes Caused by Dominant, Recessive, or Compound Heterozygous SUR1 Mutations with Opposite Functional Effects

Por Ellard, Sian , Flanagan, Sarah E. , Girard, Christophe A. , Patch, Ann-Marie , Harries, Lorna W. , Parrish, Andrew , Edghill, Emma L. , Mackay, Deborah J. G. , Proks, Peter , Shimomura, Kenju , Haberland, Holger , Carson, Dennis J. , Shield, Julian P. H. , Hattersley, Andrew T. , Ashcroft, Frances M. 
Publicado em 2007

Expression of an activating mutation in the gene encoding the K(ATP) channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Por Girard, Christophe A., Wunderlich, F. Thomas, Shimomura, Kenju, Collins, Stephan, Kaizik, Stephan, Proks, Peter, Abdulkader, Fernando, Clark, Anne, Ball, Vicky, Zubcevic, Lejla, Bentley, Liz, Clark, Rebecca, Church, Chris, Hugill, Alison, Galvanovskis, Juris, Cox, Roger, Rorsman, Patrik, Brüning, Jens C., Ashcroft, Frances M.
Publicado em 2008

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells...

Por Arredouani, Abdelilah, Ruas, Margarida, Collins, Stephan C., Parkesh, Raman, Clough, Frederick, Pillinger, Toby, Coltart, George, Rietdorf, Katja, Royle, Andrew, Johnson, Paul, Braun, Matthias, Zhang, Quan, Sones, William, Shimomura, Kenju, Morgan, Anthony J., Lewis, Alexander M., Chuang, Kai-Ting, Tunn, Ruth, Gadea, Joaquin, Teboul, Lydia, Heister, Paula M., Tynan, Patricia W., Bellomo, Elisa A., Rutter, Guy A., Rorsman, Patrik, Churchill, Grant C., Parrington, John, Galione, Antony
Publicado no J Biol Chem (2015)