A universally conserved residue in the SUR1 subunit of the K(ATP) channel is essential for translating nucleotide binding at SUR1 into channel opening

The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (K(ATP)) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation. We identified a residue in NBD2 (G1401) that is fully con...

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Hlavní autoři: de Wet, Heidi, Shimomura, Kenju, Aittoniemi, Jussi, Ahmad, Nawaz, Lafond, Mathilde, Sansom, Mark SP, Ashcroft, Frances M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2012
Témata:
Molecular and Cellular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495298/
https://ncbi.nlm.nih.gov/pubmed/22802590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.236075
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