SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator

SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive (K(ATP)) channel is an octameric complex of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits, and it...

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Detalhes bibliográficos
Main Authors: Aittoniemi, Jussi, Fotinou, Constantina, Craig, Tim J., de Wet, Heidi, Proks, Peter, Ashcroft, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2008
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674095/
https://ncbi.nlm.nih.gov/pubmed/18990670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2008.0142
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