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Molecular Mechanism of Sulphonylurea Block of K(ATP) Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
Sulphonylurea drugs are the therapy of choice for treating neonatal diabetes (ND) caused by mutations in the ATP-sensitive K(+) channel (K(ATP) channel). We investigated the interactions between MgATP, MgADP, and the sulphonylurea gliclazide with K(ATP) channels expressed in Xenopus oocytes. In the...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Diabetes Association
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806600/ https://ncbi.nlm.nih.gov/pubmed/23835339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0531 |
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