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Molecular action of sulphonylureas on K(ATP) channels: a real partnership between drugs and nucleotides
Sulphonylureas stimulate insulin secretion from pancreatic β-cells primarily by closing ATP-sensitive K(+) channels in the β-cell plasma membrane. The mechanism of channel inhibition by these drugs is unusually complex. As direct inhibitors of channel activity, sulphonylureas act only as partial ant...
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| Publicado no: | Biochem Soc Trans |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613533/ https://ncbi.nlm.nih.gov/pubmed/26517901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20150096 |
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