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Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP

The β cell K(ATP) channel is an octameric complex of four pore-forming subunits (Kir6.2) and four regulatory subunits (SUR1). A truncated isoform of Kir6.2 (Kir6.2ΔC26), which expresses independently of SUR1, shows intrinsic ATP sensitivity, suggesting that this subunit is primarily responsible for...

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Hlavní autoři: Trapp, Stefan, Proks, Peter, Tucker, Stephen J., Ashcroft, Frances M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229413/
https://ncbi.nlm.nih.gov/pubmed/9725893
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