Involvement of the N-terminus of Kir6.2 in the inhibition of the K(ATP) channel by ATP

1. ATP-sensitive potassium (K(ATP)) channels are composed of pore-forming Kir6.2 and regulatory SUR subunits. A truncated isoform of Kir6.2, Kir6.2ΔC26, expresses ATP-sensitive channels in the absence of SUR1, suggesting the ATP-inhibitory site lies on the Kir6.2 subunit. 2. We examined the effect o...

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Main Authors: Proks, Peter, Gribble, Fiona M, Adhikari, Raju, Tucker, Stephen J, Ashcroft, Frances M
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 1999
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269058/
https://ncbi.nlm.nih.gov/pubmed/9831713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.019af.x
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