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Functional analysis of a structural model of the ATP-binding site of the K(ATP) channel Kir6.2 subunit
ATP-sensitive potassium (K(ATP)) channels couple cell metabolism to electrical activity by regulating K(+) flux across the plasma membrane. Channel closure is mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we use homology modelling and ligand docking to construct a model of...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545803/ https://ncbi.nlm.nih.gov/pubmed/15650751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600487 |
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