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Functional analysis of a structural model of the ATP-binding site of the K(ATP) channel Kir6.2 subunit

ATP-sensitive potassium (K(ATP)) channels couple cell metabolism to electrical activity by regulating K(+) flux across the plasma membrane. Channel closure is mediated by ATP, which binds to the pore-forming subunit (Kir6.2). Here we use homology modelling and ligand docking to construct a model of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Antcliff, Jennifer F, Haider, Shozeb, Proks, Peter, Sansom, Mark S P, Ashcroft, Frances M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC545803/
https://ncbi.nlm.nih.gov/pubmed/15650751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600487
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