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Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification

ATP-sensitive potassium (K(ATP)) channels are reversibly inhibited by intracellular ATP. Agents that interact with sulfhydryl moieties produce an irreversible inhibition of K(ATP) channel activity when applied to the intracellular membrane surface. ATP appears to protect against this effect, suggest...

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Détails bibliographiques
Auteurs principaux: Trapp, Stefan, Tucker, Stephen J., Ashcroft, Frances M.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 1998
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229416/
https://ncbi.nlm.nih.gov/pubmed/9725892
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