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Analysis of the differential modulation of sulphonylurea block of β-cell and cardiac ATP-sensitive K(+) (K(ATP)) channels by Mg-nucleotides
Sulphonylureas stimulate insulin secretion by binding with high-affinity to the sulphonylurea receptor (SUR) subunit of the ATP-sensitive potassium (K(ATP)) channel and thereby closing the channel pore (formed by four Kir6.2 subunits). In the absence of added nucleotides, the maximal block is around...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342633/ https://ncbi.nlm.nih.gov/pubmed/12562963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.031625 |
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