Analysis of the differential modulation of sulphonylurea block of β-cell and cardiac ATP-sensitive K(+) (K(ATP)) channels by Mg-nucleotides

Sulphonylureas stimulate insulin secretion by binding with high-affinity to the sulphonylurea receptor (SUR) subunit of the ATP-sensitive potassium (K(ATP)) channel and thereby closing the channel pore (formed by four Kir6.2 subunits). In the absence of added nucleotides, the maximal block is around...

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Hlavní autoři: Reimann, Frank, Dabrowski, Michael, Jones, Phillippa, Gribble, Fiona M, Ashcroft, Frances M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2003
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342633/
https://ncbi.nlm.nih.gov/pubmed/12562963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.031625
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