PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2(−/−) Lep(ob)/Lep(ob) (POKO mouse), resulted in decreased fat mass, severe insulin resistance, β-cell failure, and dyslipidaemia. Our results...

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Detalhes bibliográficos
Main Authors: Medina-Gomez, Gema, Gray, Sarah L, Yetukuri, Laxman, Shimomura, Kenju, Virtue, Sam, Campbell, Mark, Curtis, R. Keira, Jimenez-Linan, Mercedes, Blount, Margaret, Yeo, Giles S. H, Lopez, Miguel, Seppänen-Laakso, Tuulikki, Ashcroft, Frances M, Orešič, Matej, Vidal-Puig, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857730/
https://ncbi.nlm.nih.gov/pubmed/17465682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030064
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