Adaptation and failure of pancreatic β cells in murine models with different degrees of metabolic syndrome

The events that contribute to the expansion of β-cell mass and enhanced β-cell function in insulin-resistant states have not been elucidated fully. Recently, we showed that β-cell adaptation failed dramatically in adult, insulin-resistant POKO mice, which contrasts with the appropriate expansion of...

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Detaylı Bibliyografya
Asıl Yazarlar: Medina-Gomez, Gema, Yetukuri, Laxman, Velagapudi, Vidya, Campbell, Mark, Blount, Margaret, Jimenez-Linan, Mercedes, Ros, Manuel, Orešič, Matej, Vidal-Puig, Antonio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Limited 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773727/
https://ncbi.nlm.nih.gov/pubmed/19841237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.003251
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