Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

Some of insulin’s functions, including glucose/lipid metabolism, satiety and neuroprotection, involve the alteration of brain activities. Insulin could signal to the brain via penetrating through the blood-brain barrier and acting on the vagal afferents, while the latter remains unproved. This study...

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Main Authors: Iwasaki, Yusaku, Shimomura, Kenju, Kohno, Daisuke, Dezaki, Katsuya, Ayush, Enkh-Amar, Nakabayashi, Hajime, Kubota, Naoto, Kadowaki, Takashi, Kakei, Masafumi, Nakata, Masanori, Yada, Toshihiko
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693960/
https://ncbi.nlm.nih.gov/pubmed/23840624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067198
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