Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca(2+) signalling and insulin secretion due to blockade of L-type Ca(2+) channels in rat islet β-cells

1. Hypercholesterolaemia often occurs in patients with type 2 diabetes, who therefore encounter administration of HMG-CoA reductase inhibitors. Alteration of pancreatic β-cell function leading to an impaired insulin secretory response to glucose plays a crucial role in the pathogenesis of type 2 dia...

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Hlavní autoři: Yada, Toshihiko, Nakata, Masanori, Shiraishi, Tomoko, Kakei, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: 1999
Témata:
Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565875/
https://ncbi.nlm.nih.gov/pubmed/10205010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702397
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