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Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca(2+) signalling and insulin secretion due to blockade of L-type Ca(2+) channels in rat islet β-cells
1. Hypercholesterolaemia often occurs in patients with type 2 diabetes, who therefore encounter administration of HMG-CoA reductase inhibitors. Alteration of pancreatic β-cell function leading to an impaired insulin secretory response to glucose plays a crucial role in the pathogenesis of type 2 dia...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565875/ https://ncbi.nlm.nih.gov/pubmed/10205010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702397 |
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