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Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca(2+) in Female Mouse Islets Stimulated by Glucose and Tolbutamide
Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)](c)) and insulin secretion in mouse islets....
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| Publicado no: | Endocrinology |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255079/ https://ncbi.nlm.nih.gov/pubmed/24977470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1247 |
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