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Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca(2+) in Female Mouse Islets Stimulated by Glucose and Tolbutamide

Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)](c)) and insulin secretion in mouse islets....

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Vydáno v:Endocrinology
Hlavní autoři: Henquin, Jean-Claude, Nenquin, Myriam
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255079/
https://ncbi.nlm.nih.gov/pubmed/24977470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1247
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