Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice

Por Sgobio, Carmelo, Sun, Lixin, Ding, Jinhui, Herms, Jochen, Lovinger, David M., Cai, Huaibin
Publicado no Sci Rep (2019)

Optogenetic Measurement of Presynaptic Calcium Transients Using Conditional Genetically Encoded Calcium Indicator Expression in Dopaminergic Neurons

Por Sgobio, Carmelo, Kupferschmidt, David A., Cui, Guohong, Sun, Lixin, Li, Zheng, Cai, Huaibin, Lovinger, David M.
Publicado em 2014

Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome

Por Restivo, Leonardo, Ferrari, Francesca, Passino, Enrica, Sgobio, Carmelo, Bock, Jörg, Oostra, Ben A., Bagni, Claudia, Ammassari-Teule, Martine
Publicado em 2005

Dopamine-Dependent Long-Term Depression Is Expressed in Striatal Spiny Neurons of Both Direct and Indirect Pathways: Implications for Parkinson's Disease

Por Bagetta, Vincenza, Picconi, Barbara, Marinucci, Silvia, Sgobio, Carmelo, Pendolino, Valentina, Ghiglieri, Veronica, Fusco, Francesca R., Giampà, Carmen, Calabresi, Paolo
Publicado no J Neurosci (2011)

Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

Por Peters, Finn, Salihoglu, Hazal, Pratsch, Katrin, Herzog, Etienne, Pigoni, Martina, Sgobio, Carmelo, Lichtenthaler, Stefan F, Neumann, Ulf, Herms, Jochen
Publicado no EMBO J (2019)

Aldehyde dehydrogenase 1–positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum

Por Sgobio, Carmelo, Wu, Junbing, Zheng, Wang, Chen, Xi, Pan, Jing, Salinas, Armando G., Davis, Margaret I., Lovinger, David M., Cai, Huaibin
Publicado no Sci Rep (2017)

No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

Por Sastry, Namratha, Zheng, Wang, Liu, Guoxiang, Wang, Helen, Chen, Xi, Cai, Michael, Contractor, Parth, Sgobio, Carmelo, Sun, Lixin, Xie, Chengsong, Cai, Huaibin
Publicado no Transl Neurodegener (2015)

Rebalance of Striatal NMDA/AMPA Receptor Ratio Underlies the Reduced Emergence of Dyskinesia During D2-Like Dopamine Agonist Treatment in Experimental Parkinson's Disease

Por Bagetta, Vincenza, Sgobio, Carmelo, Pendolino, Valentina, Del Papa, Giulia, Tozzi, Alessandro, Ghiglieri, Veronica, Giampà, Carmela, Zianni, Elisa, Gardoni, Fabrizio, Calabresi, Paolo, Picconi, Barbara
Publicado no J Neurosci (2012)

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Por Parisiadou, Loukia, Yu, Jia, Sgobio, Carmelo, Xie, Chengsong, Liu, Guoxiang, Sun, Lixin, Gu, Xing-Long, Lin, Xian, Crowley, Nicole A., Lovinger, David, Cai, Huaibin
Publicado em 2014

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

Por Zou, Chengyu, Crux, Sophie, Marinesco, Stephane, Montagna, Elena, Sgobio, Carmelo, Shi, Yuan, Shi, Song, Zhu, Kaichuan, Dorostkar, Mario M, Müller, Ulrike C, Herms, Jochen
Publicado no EMBO J (2016)

TrkB/BDNF-Dependent Striatal Plasticity and Behavior in a Genetic Model of Epilepsy: Modulation by Valproic Acid

Por Ghiglieri, Veronica, Sgobio, Carmelo, Patassini, Stefano, Bagetta, Vincenza, Fejtova, Anna, Giampà, Carmela, Marinucci, Silvia, Heyden, Alexandra, Gundelfinger, Eckart D, Fusco, Francesca R, Calabresi, Paolo, Picconi, Barbara
Publicado em 2010

α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals

Por Xu, Jianhua, Wu, Xin-Sheng, Sheng, Jiansong, Zhang, Zhen, Yue, Hai-Yuan, Sun, Lixin, Sgobio, Carmelo, Lin, Xian, Peng, Shiyong, Jin, Yinghui, Gan, Lin, Cai, Huaibin, Wu, Ling-Gang
Publicado no J Neurosci (2016)

Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition

Por Paillé, Vincent, Picconi, Barbara, Bagetta, Vincenza, Ghiglieri, Veronica, Sgobio, Carmelo, Di Filippo, Massimiliano, Viscomi, Maria T., Giampà, Carmela, Fusco, Francesca R., Gardoni, Fabrizio, Bernardi, Giorgio, Greengard, Paul, Di Luca, Monica, Calabresi, Paolo
Publicado no J Neurosci (2010)

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic...

Por Liu, Guoxiang, Sgobio, Carmelo, Gu, Xinglong, Sun, Lixin, Lin, Xian, Yu, Jia, Parisiadou, Loukia, Xie, Chengsong, Sastry, Namratha, Ding, Jinhui, Lohr, Kelly M., Miller, Gary W., Mateo, Yolanda, Lovinger, David M., Cai, Huaibin
Publicado no Hum Mol Genet (2015)

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease

Por Dunn, Amy R., Stout, Kristen A., Ozawa, Minagi, Lohr, Kelly M., Hoffman, Carlie A., Bernstein, Alison I., Li, Yingjie, Wang, Minzheng, Sgobio, Carmelo, Sastry, Namratha, Cai, Huaibin, Caudle, W. Michael, Miller, Gary W.
Publicado no Proc Natl Acad Sci U S A (2017)

Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription...

Por Lin, Xian, Parisiadou, Loukia, Sgobio, Carmelo, Liu, Guoxiang, Yu, Jia, Sun, Lixin, Shim, Hoon, Gu, Xing-Long, Luo, Jing, Long, Cai-Xia, Ding, Jinhui, Mateo, Yolanda, Sullivan, Patricia H., Wu, Ling-Gang, Goldstein, David S., Lovinger, David, Cai, Huaibin
Publicado em 2012

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model

Por Sacher, Christian, Blume, Tanja, Beyer, Leonie, Peters, Finn, Eckenweber, Florian, Sgobio, Carmelo, Deussing, Maximilian, Albert, Nathalie L., Unterrainer, Marcus, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Brzak, Irena, Neumann, Ulf, Saito, Takashi, Saido, Takaomi C., Bartenstein, Peter, Rominger, Axel, Herms, Jochen, Brendel, Matthias
Publicado no J Nucl Med (2019)