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LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). Here we show that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subuni...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989289/ https://ncbi.nlm.nih.gov/pubmed/24464040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3636 |
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