Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

Preferential dysfunction/degeneration of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main movement symptoms manifested in Parkinson's disease (PD). Although the Leucine-rich repeat kinase 2 (LRRK2) G2019S missense mutation (LRRK2 G2019S) is the mo...

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Publicado no:Hum Mol Genet
Main Authors: Liu, Guoxiang, Sgobio, Carmelo, Gu, Xinglong, Sun, Lixin, Lin, Xian, Yu, Jia, Parisiadou, Loukia, Xie, Chengsong, Sastry, Namratha, Ding, Jinhui, Lohr, Kelly M., Miller, Gary W., Mateo, Yolanda, Lovinger, David M., Cai, Huaibin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550828/
https://ncbi.nlm.nih.gov/pubmed/26123485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv249
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