Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model

Nonphysiologic overexpression of amyloid-β (Aβ) precursor protein in common transgenic Aβ mouse models of Alzheimer disease likely hampers their translational potential. The novel App(NL-G-F) mouse incorporates a mutated knock-in, potentially presenting an improved model of Alzheimer disease for Aβ-...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Sacher, Christian, Blume, Tanja, Beyer, Leonie, Peters, Finn, Eckenweber, Florian, Sgobio, Carmelo, Deussing, Maximilian, Albert, Nathalie L., Unterrainer, Marcus, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Brzak, Irena, Neumann, Ulf, Saito, Takashi, Saido, Takaomi C., Bartenstein, Peter, Rominger, Axel, Herms, Jochen, Brendel, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2019
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894380/
https://ncbi.nlm.nih.gov/pubmed/31302633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.119.227322
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