Integrating pathology into human disease modelling – how to eat the elephant

Por Scudamore, Cheryl L.
Publicado em 2014

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

Por Alliouachene, Samira, Bilanges, Benoit, Chaussade, Claire, Pearce, Wayne, Foukas, Lazaros C., Scudamore, Cheryl L., Moniz, Larissa S., Vanhaesebroeck, Bart
Publicado no Diabetologia (2016)

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles

Por Elshorbagy, Amany K., Jernerén, Fredrik, Scudamore, Cheryl L., McMurray, Fiona, Cater, Heather, Hough, Tertius, Cox, Roger, Refsum, Helga
Publicado no PLoS One (2016)

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Por Stark, Anne-Katrien, Davenport, Elizabeth C. M., Patton, Daniel T., Scudamore, Cheryl L., Vanhaesebroeck, Bart, Veldhoen, Marc, Garden, Oliver A., Okkenhaug, Klaus
Publicado no J Immunol (2020)

Histochemical and Ultrastructural Modification of Mucosal Mast Cell Granules in Parasitized Mice Lacking the β-Chymase, Mouse Mast Cell Protease-1

Por Wastling, Jonathan M., Knight, Pamela, Ure, Jan, Wright, Steven, Thornton, Elisabeth M., Scudamore, Cheryl L., Mason, John, Smith, Austin, Miller, Hugh R. P.
Publicado em 1998

Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis

Por Verbiest, Tom, Finnon, Rosemary, Brown, Natalie, Cruz-Garcia, Lourdes, Finnon, Paul, O’Brien, Grainne, Ross, Eleanor, Bouffler, Simon, Scudamore, Cheryl L., Badie, Christophe
Publicado no Leukemia (2018)

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice

Por Podrini, Christine, Cambridge, Emma L., Lelliott, Christopher J., Carragher, Damian M., Estabel, Jeanne, Gerdin, Anna-Karin, Karp, Natasha A., Scudamore, Cheryl L., Ramirez-Solis, Ramiro, White, Jacqueline K.
Publicado em 2013

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

Por Al-Jazzar, Ahmed, Javaheri, Behzad, Prideaux, Matt, Boyde, Alan, Scudamore, Cheryl L., Cherifi, Chahrazad, Hay, Eric, Hopkinson, Mark, Boyd, Michael, Cohen-Solal, Martine, Farquharson, Colin, Pitsillides, Andrew A.
Publicado no Int J Mol Sci (2016)

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

Por Hugill, Alison J., Stewart, Michelle E., Yon, Marianne A., Probert, Fay, Cox, I. Jane, Hough, Tertius A., Scudamore, Cheryl L., Bentley, Liz, Wall, Gary, Wells, Sara E., Cox, Roger D.
Publicado no Biol Open (2015)

Metabolic Profiling of the Rat Liver After Chronic Ingestion of Alpha-Naphthylisothiocyanate Using In Vivo and Ex Vivo Magnetic Resonance Spectroscopy

Por Solanky, Bhavana S., Sanchez-Canon, Gina J., Cobbold, Jeremy F. L., Taylor-Robinson, Simon D., Bell, Jimmy D., Scudamore, Cheryl L., Ross, Eleanor, Holder, Julie C., So, Po-Wah, Cox, I. Jane
Publicado em 2012

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

Por Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
Publicado no Nature (2014)

Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background

Por Falcone, Sara, Wisby, Laura, Nicol, Thomas, Blease, Andrew, Starbuck, Becky, Parker, Andrew, Sanderson, Jeremy, Brown, Steve D. M., Scudamore, Cheryl L., Pusey, Charles D., Tam, Frederick W. K., Potter, Paul K.
Publicado no Sci Rep (2019)

Radiosensitisation in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity

Por Groselj, Blaz, Ruan, Jia-Ling, Scott, Helen, Gorrill, Jessica, Nicholson, Judith, Kelly, Jacqueline, Anbalagan, Selvakumar, Thompson, James, Stratford, Michael RL, Jevons, Sarah J, Hammond, Ester M, Scudamore, Cheryl L, Kerr, Martin, Kiltie, Anne E
Publicado no Mol Cancer Ther (2017)

Pharmacological Inhibition of FTO

Por McMurray, Fiona, Demetriades, Marina, Aik, WeiShen, Merkestein, Myrte, Kramer, Holger, Andrew, Daniel S., Scudamore, Cheryl L., Hough, Tertius A., Wells, Sara, Ashcroft, Frances M., McDonough, Michael A., Schofield, Christopher J., Cox, Roger D.
Publicado no PLoS One (2015)

Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression

Por Warr, Nick, Carre, Gwenn-Aël, Siggers, Pam, Faleato, Jessica Vitos, Brixey, Rachel, Pope, Madeleine, Bogani, Debora, Childers, Melissa, Wells, Sara, Scudamore, Cheryl L., Tedesco, Marianna, del Barco Barrantes, Ivan, Nebreda, Angel R., Trainor, Paul A., Greenfield, Andy
Publicado em 2012

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

Por Alliouachene, Samira, Bilanges, Benoit, Chicanne, Gaëtan, Anderson, Karen E., Pearce, Wayne, Ali, Khaled, Valet, Colin, Posor, York, Low, Pei Ching, Chaussade, Claire, Scudamore, Cheryl L., Salamon, Rachel S., Backer, Jonathan M., Stephens, Len, Hawkins, Phill T., Payrastre, Bernard, Vanhaesebroeck, Bart
Publicado no Cell Rep (2015)

International Recommendations for Training Future Toxicologic Pathologists Participating in Regulatory-Type, Nonclinical Toxicity Studies

Por Bolon, Brad, Barale-Thomas, Erio, Bradley, Alys, Ettlin, Robert A., Franchi, Carla A.S., George, Catherine, Giusti, Anna Maria, Hall, Robert, Jacobsen, Matthew, Konishi, Yoichi, Ledieu, David, Morton, Daniel, Park, Jae-Hak, Scudamore, Cheryl L., Tsuda, Hiroyuki, Vijayasarathi, S.K., Wijnands, Marcel V.W.
Publicado em 2010

An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

Por Bentley, Liz, Esapa, Christopher T., Nesbit, M. Andrew, Head, Rosie A., Evans, Holly, Lath, Darren, Scudamore, Cheryl L., Hough, Tertius A., Podrini, Christine, Hannan, Fadil M., Fraser, William D., Croucher, Peter I., Brown, Matthew A., Brown, Steve D. M., Cox, Roger D., Thakker, Rajesh V.
Publicado em 2014

Targeting of Slc25a21 Is Associated with Orofacial Defects and Otitis Media Due to Disrupted Expression of a Neighbouring Gene

Por Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M., Walker, Nicolas, Bussell, James, Chan, Wai-In, Keane, Thomas M., Adams, David J., Scudamore, Cheryl L., Lelliott, Christopher J., Ramírez-Solis, Ramiro, Karp, Natasha A., Steel, Karen P., White, Jacqueline K., Gerdin, Anna-Karin
Publicado em 2014

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

Por Herbert, Eleanor, Stewart, Michelle, Hutchison, Marie, Flenniken, Ann M., Qu, Dawei, Nutter, Lauryl M. J., McKerlie, Colin, Hobson, Liane, Kick, Brenda, Lyons, Bonnie, Wiegand, Jean-Paul, Doty, Rosalinda, Aguilar-Pimentel, Juan Antonio, Hrabe de Angelis, Martin, Dickinson, Mary, Seavitt, John, White, Jacqueline K., Scudamore, Cheryl L., Wells, Sara
Publicado no PLoS One (2020)