Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

In contrast to the class I phosphoinositide 3-kinases (PI3Ks), the organismal roles of the kinase activity of the class II PI3Ks are less clear. Here, we report that class II PI3K-C2β kinase-dead mice are viable and healthy but display an unanticipated enhanced insulin sensitivity and glucose tolera...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Alliouachene, Samira, Bilanges, Benoit, Chicanne, Gaëtan, Anderson, Karen E., Pearce, Wayne, Ali, Khaled, Valet, Colin, Posor, York, Low, Pei Ching, Chaussade, Claire, Scudamore, Cheryl L., Salamon, Rachel S., Backer, Jonathan M., Stephens, Len, Hawkins, Phill T., Payrastre, Bernard, Vanhaesebroeck, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675724/
https://ncbi.nlm.nih.gov/pubmed/26655903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.052
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