A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth

To uncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs) and platelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34(lox/lox)). Deletion of Vps34 in MKs led to the loss of its regulator protein, Vps15, and wa...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Valet, Colin, Levade, Marie, Chicanne, Gaëtan, Bilanges, Benoit, Cabou, Cendrine, Viaud, Julien, Gratacap, Marie-Pierre, Gaits-Iacovoni, Frédérique, Vanhaesebroeck, Bart, Payrastre, Bernard, Severin, Sonia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669208/
https://ncbi.nlm.nih.gov/pubmed/28903944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-04-781641
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