The Nucleophosmin-Anaplastic Lymphoma Kinase Oncogene Interacts, Activates, and Uses the Kinase PIKfyve to Increase Invasiveness

NPM-ALK is a chimeric tyrosine kinase detected in most anaplastic large cell lymphomas that results from the reciprocal translocation t(2,5)(p23;q35) that fuses the N-terminal domain of nucleophosmin (NPM) to the catalytic domain of the anaplastic lymphoma kinase (ALK) receptor. The constitutive act...

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Main Authors: Dupuis-Coronas, Sophie, Lagarrigue, Frédéric, Ramel, Damien, Chicanne, Gaëtan, Saland, Estelle, Gaits-Iacovoni, Frédérique, Payrastre, Bernard, Tronchère, Hélène
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173219/
https://ncbi.nlm.nih.gov/pubmed/21737449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227512
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