The Nucleophosmin-Anaplastic Lymphoma Kinase Oncogene Interacts, Activates, and Uses the Kinase PIKfyve to Increase Invasiveness

NPM-ALK is a chimeric tyrosine kinase detected in most anaplastic large cell lymphomas that results from the reciprocal translocation t(2,5)(p23;q35) that fuses the N-terminal domain of nucleophosmin (NPM) to the catalytic domain of the anaplastic lymphoma kinase (ALK) receptor. The constitutive act...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Dupuis-Coronas, Sophie, Lagarrigue, Frédéric, Ramel, Damien, Chicanne, Gaëtan, Saland, Estelle, Gaits-Iacovoni, Frédérique, Payrastre, Bernard, Tronchère, Hélène
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173219/
https://ncbi.nlm.nih.gov/pubmed/21737449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227512
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi