Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not completely understood. Here we show that heterozygous Vps34 kinase-dead mice...

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出版年:Nat Commun
主要な著者: Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703854/
https://ncbi.nlm.nih.gov/pubmed/29180704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01969-4
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