Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability

Por Wilkes, Edmund H., Casado, Pedro, Rajeeve, Vinothini, Cutillas, Pedro R.
Publicado no Mol Cell Proteomics (2017)

Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells

Por Casado, Pedro, Bilanges, Benoit, Rajeeve, Vinothini, Vanhaesebroeck, Bart, Cutillas, Pedro R.
Publicado em 2014

Cross-species Proteomics Reveals Specific Modulation of Signaling in Cancer and Stromal Cells by Phosphoinositide 3-kinase (PI3K) Inhibitors

Por Rajeeve, Vinothini, Vendrell, Iolanda, Wilkes, Edmund, Torbett, Neil, Cutillas, Pedro R.
Publicado em 2014

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma

Por Simon, Thomas, Pinioti, Sotiria, Schellenberger, Pascale, Rajeeve, Vinothini, Wendler, Franz, Cutillas, Pedro R., King, Alice, Stebbing, Justin, Giamas, Georgios
Publicado no Mol Cancer (2018)

Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

Por Arnandis, Teresa, Monteiro, Pedro, Adams, Sophie D., Bridgeman, Victoria Louise, Rajeeve, Vinothini, Gadaleta, Emanuela, Marzec, Jacek, Chelala, Claude, Malanchi, Ilaria, Cutillas, Pedro R., Godinho, Susana A.
Publicado no Dev Cell (2018)

Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells

Por Casado, Pedro, Wilkes, Edmund H., Miraki-Moud, Farideh, Hadi, Marym Mohammad, Rio-Machin, Ana, Rajeeve, Vinothini, Pike, Rebecca, Iqbal, Sameena, Marfa, Santiago, Lea, Nicholas, Best, Steven, Gribben, John, Fitzgibbon, Jude, Cutillas, Pedro R.
Publicado no Leukemia (2018)

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Por Quétier, Ivan, Marshall, Jacqueline J.T., Spencer-Dene, Bradley, Lachmann, Sylvie, Casamassima, Adele, Franco, Claudio, Escuin, Sarah, Worrall, Joseph T., Baskaran, Priththivika, Rajeeve, Vinothini, Howell, Michael, Copp, Andrew J., Stamp, Gordon, Rosewell, Ian, Cutillas, Pedro, Gerhardt, Holger, Parker, Peter J., Cameron, Angus J.M.
Publicado no Cell Rep (2016)

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

Por Angulo-Urarte, Ana, Casado, Pedro, Castillo, Sandra D., Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana M., Castel, Pau, Rajeeve, Vinothini, Milà-Guasch, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laia, Casanovas, Oriol, Viñals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R., Graupera, Mariona
Publicado no Nat Commun (2018)

Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants

Por Tummala, Hemanth, Dokal, Arran D., Walne, Amanda, Ellison, Alicia, Cardoso, Shirleny, Amirthasigamanipillai, Saranha, Kirwan, Michael, Browne, Isobel, Sidhu, Jasmin K., Rajeeve, Vinothini, Rio-Machin, Ana, Seraihi, Ahad Al, Duncombe, Andrew S., Jenner, Matthew, Smith, Owen P., Enright, Helen, Norton, Alice, Aksu, Tekin, Özbek, Namık Yaşar, Pontikos, Nikolas, Cutillas, Pedro, Dokal, Inderjeet, Vulliamy, Tom
Publicado no Proc Natl Acad Sci U S A (2018)

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Por Sciacovelli, Marco, Gonçalves, Emanuel, Isaac Johnson, Timothy, Roberto Zecchini, Vincent, da Costa, Ana Sofia Henriques, Gaude, Edoardo, Vercauteren Drubbel, Alizee, Julian Theobald, Sebastian, Abbo, Sandra, Tran, Maxine, Rajeeve, Vinothini, Cardaci, Simone, Foster, Sarah, Yun, Haiyang, Cutillas, Pedro, Warren, Anne, Gnanapragasam, Vincent, Gottlieb, Eyal, Franze, Kristian, Huntly, Brian, Richard Maher, Eamonn, Henry Maxwell, Patrick, Saez-Rodriguez, Julio, Frezza, Christian
Publicado no Nature (2016)

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers

Por Pearce, Oliver M T, Delaine-Smith, Robin, Maniati, Eleni, Nichols, Sam, Wang, Jun, Böhm, Steffen, Rajeeve, Vinothini, Ullah, Dayem, Chakravarty, Probir, Jones, Roanne R., Montfort, Anne, Dowe, Tom, Gribben, John, Jones, J. Louise, Kocher, Hemant M, Serody, Jonathan S, Vincent, Benjamin G, Connelly, John, Brenton, James D., Chelala, Claude, Cutillas, Pedro R., Lockley, Michelle, Bessant, Conrad, Knight, Martin, Balkwill, Frances R
Publicado no Cancer Discov (2017)

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Por Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
Publicado no Nat Commun (2017)