Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Mutations of the tricarboxylic acid cycle (TCA cycle) enzyme fumarate hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)1. FH-deficient renal cancers are highly aggressive and metastasise even when small, leading to an abysmal clinical outcome2. Fumarate, a small molecule m...

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Publicado no:Nature
Main Authors: Sciacovelli, Marco, Gonçalves, Emanuel, Isaac Johnson, Timothy, Roberto Zecchini, Vincent, da Costa, Ana Sofia Henriques, Gaude, Edoardo, Vercauteren Drubbel, Alizee, Julian Theobald, Sebastian, Abbo, Sandra, Tran, Maxine, Rajeeve, Vinothini, Cardaci, Simone, Foster, Sarah, Yun, Haiyang, Cutillas, Pedro, Warren, Anne, Gnanapragasam, Vincent, Gottlieb, Eyal, Franze, Kristian, Huntly, Brian, Richard Maher, Eamonn, Henry Maxwell, Patrick, Saez-Rodriguez, Julio, Frezza, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136292/
https://ncbi.nlm.nih.gov/pubmed/27580029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19353
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