Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still unclear. Here, we used mouse and human cell lines to...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tyrakis, Petros A., Yurkovich, Marie E., Sciacovelli, Marco, Papachristou, Evangelia K., Bridges, Hannah R., Gaude, Edoardo, Schreiner, Alexander, D’Santos, Clive, Hirst, Judy, Hernandez-Fernaud, Juan, Springett, Roger, Griffiths, John R., Frezza, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668630/
https://ncbi.nlm.nih.gov/pubmed/29069586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.092
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