Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still unclear. Here, we used mouse and human cell lines to...

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Pubblicato in:Cell Rep
Autori principali: Tyrakis, Petros A., Yurkovich, Marie E., Sciacovelli, Marco, Papachristou, Evangelia K., Bridges, Hannah R., Gaude, Edoardo, Schreiner, Alexander, D’Santos, Clive, Hirst, Judy, Hernandez-Fernaud, Juan, Springett, Roger, Griffiths, John R., Frezza, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668630/
https://ncbi.nlm.nih.gov/pubmed/29069586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.092
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